Opioid drugs are highly effective at relieving pain but come with severe drawbacks. Their side effects range from dizziness to potentially fatal respiratory depression. Their illegal use contributes ...

A local health expert is raising awareness about opioid overdose prevention, the risks of an overdose during spring break, ...

Pain is personal and highly subjective. An event that causes excruciating intolerable agony for one person might be perceived by another as distressing but bearable. Even the same person may have a ...

An experimental drug developed at Duke University School of Medicine could offer powerful pain relief without the dangerous side effects of opioids. The drug, called SBI-810, is part of a new ...

Older adults in New Jersey recorded the highest number of suspected overdose deaths in 2025, according to the New Jersey ...

Scientists are racing to redesign how powerful painkillers work, aiming to keep the relief that opioids provide while stripping away the worst dangers of addiction and overdose. Instead of tweaking ...

Kappa-opioid receptor (KOR) agonists represent a promising class of compounds that modulate pain, mood and various neurobehavioural processes. Unlike traditional opioids that primarily target the ...

Researchers have developed a compound that relieves pain in mice but doesn't affect the brain, thereby avoiding mind-altering side effects and abuse potential. The custom-designed molecule, derived ...